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Updated: Feb 14, 2026

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ハイドロキシクロロクイン・レチノパシーにおける光学相関性トモグラフィーと血管図: ネラティブ・レビュー
Alexandra Lori Donica1,2, Vlad Constantin Donica1, Mara Russu1,2
1Grigore T. Popa University of Medicine and Pharmacy, University Street, No. 16, 700115 Iasi, Romania.
Diagnostics (Basel, Switzerland)
|February 13, 2026
まとめ
ヒドロキシクロロクイン (HCQ) レチノパシーのリスクは,投与量と持続時間に関連しています. オプティカルコヘレンストモグラフィ (OCT) とOCT血管図 (OCT-A) は,網膜の変化を早期に検出し,視力低下を予防するために適切な介入を助けます.
科学分野:
- オフタルモロジック (眼科)
- レウマトロジーの病理学
- 薬理学 薬理学とは
背景:
- ハイドロキシクロロクイン (HCQ) は,自己免疫疾患において極めて重要であるが,網膜の毒性を引き起こす危険性がある.
- HCQ網膜症の早期発見は,不可逆的な視力障害を予防するために不可欠です.
研究 の 目的:
- 早期のヒドロキシクロロクイン網膜病変の検出のために,光学一貫性トモグラフィ (OCT) とOCT-血管図 (OCT-A) に関する文献をレビューする.
- HCQの毒性の構造的およびマイクロ血管バイオマーカーを特定する.
主な方法:
- 2017年1月~2025年2月にPubMed.から出版された研究の物語的文献レビュー.
- 対象となった研究は,ヒトにおけるOCTおよび/またはOCT-Aを用いてHCQの毒性を評価した研究である.
- 患者の特徴,HCQ用量,画像検査の結果に関するデータを抽出します.
主要な成果:
- 223件のレビューされた研究のうち88件は,早期のHCQ毒性に関連した構造的OCT変化 (円形ゾーン,外核層,RPE) を示した.
- OCT-Aでは,血管の密度が低下し,フーヴェア・アヴァスキュラーゾーンの拡大などのマイクロ血管の変化が明らかになった.
- これらのイメージングの発見は,しばしば機能的視力障害に先行した.
結論:
- HCQ網膜症は,累積的な用量,持続時間,患者要因に関連する深刻なリスクです.
- OCTとOCT-Aは,亜臨床的網膜毒性の検出のための補完的なバイオマーカーを提供しています.
- 定量的なOCT指標を統合することで,スクリーニング,診断,個別化された患者ケアを向上させることができます.
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