フーリエ変換赤外線光譜を用いた頭頸部がんの呼気分析: 非侵襲的スクリーニングの可行性研究

Kota Nakasuji¹, Yoshihito Tanaka¹, Masato Yamamoto²

¹Department of Otorhinolaryngology-Head and Neck, Odawara Municipal Hospital, Kanagawa 250-8558, Japan.

Diagnostics (Basel, Switzerland)

|February 13, 2026

まとめ

フーリエ変換赤外線 (FTIR) 射出呼吸のスペクトロスコーピーは,非侵襲的な頭頸部がん検診の有望性を示しています. この方法は,早期発見のための内視鏡検査の実現可能な代替案を提供します.

科学分野:

バイオメディカルエンジニアリング
スペクトロスコーピーは,スペクトロスコーピーを用います.
腫瘍学腫瘍学

背景:

頭頸部がんの早期発見は,患者の治療結果を改善します.
エンドスコピーのような現在のスクリーニング方法は侵襲的で,専門的な専門知識が必要です.
よりシンプルで非侵襲的なスクリーニングツールが必要です.

研究の目的:

フーリエ変換赤外線 (FTIR) スペクトロスコピーの臨床的可行性を評価し,頭頸部がんの非侵襲的スクリーニングツールとして吐いた息を分析する.

主な方法:

頭頸部がん患者 (n=10) と健康な対照群 (n=14) の呼気サンプルをFTIRスペクトル検査で分析した.
赤外線吸収スペクトルをグループ間で比較した.
受信機運用特性 (ROC) 分析が行われました.

主要な成果:

FTIRスペクトロスコーピーは,患者と対照群 (2691の波数点,p <0.05) の間の呼吸スペクトルの有意な違いを特定しました.
特定の波数 (3917.3cm−1) は強い差異を示した (p = 0.00015).
ROC分析は,0.929の曲線の下の領域を示し,良き差別的パフォーマンスを示した.

結論:

FTIRベースの呼気分析は,頭頸部がんをスクリーニングするための非侵襲的で実行可能な方法です.
この技術は,がんのスクリーニングにおける臨床応用の可能性を示しています.
このアプローチは,他の病気の検出にも適応できるかもしれません.

キーワード:

FTIRは,FTIRであるため,吐き出された息は,吐き出された呼吸です.頭頸部がんは,頭頸部がんである.スクリーニング・スクリーニング

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