メラノマのプレゼンテーション,COVID-19のパンデミック前,中,そしてその後:ドイツのノースライン=ウェストファリアの多センターコホート研究
Thilo Gambichler1,2,3, Carmen Colo2, Sera Selina Weyer-Fahlbusch1
1Department of Dermatology, Dortmund Hospital gGmbH, University Witten/Herdecke, 44137 Dortmund, Germany.
Cancers
|February 13, 2026
まとめ
COVID-19の流行は,ドイツの病院コホートにおけるメラノーマ腫瘍の厚さを増加させなかった. しかし,流行後の早期メラノーマの診断は少なく,検出と紹介経路の継続的な障害を示唆しています.
科学分野:
- 皮膚科 皮膚科について
- 腫瘍学 腫瘍学
- エピデミオロジー エピデミオロジー
背景:
- COVID-19のパンデミックは,通常の皮膚科のケアに影響を与え,メラノーマの診断と治療を遅らせる可能性がある.
- 流行後期におけるメラノーマの発現に関するデータは限られているが,特に病院での紹介コーホートでは限られている.
- この研究では,ドイツのCOVID-19パンデミック前,中,および後のメラノーマのプレゼンテーションパターンを調査しました.
研究 の 目的:
- メラノーマのプレゼンテーションの特徴に対するCOVID-19のパンデミックの影響を評価する.
- 異なるパンデミックフェーズにおけるブレズロー腫瘍の厚さ (TT) とAJCCのステージの変化を分析する.
- 早期メラノーマ検出と紹介経路に対する潜在的な長期的な影響を特定する.
主な方法:
- 多中心の遡及的なコホート研究では,パンデミック前,パンデミック中,そしてパンデミック後の3つの段階にわたる皮膚性メラノーマの入院患者2960人が含まれていました.
- 主なエンドポイントは,多変数回帰を用いて分析された侵襲性メラノーマのブレロー腫瘍厚さ (TT) でした.
- 二次評価のエンドポイントには,Tカテゴリー,AJCCステージ,腫瘍の大きさ,ステージ設定,検査パラメータが含まれていました.
主要な成果:
- 侵襲性メラノーマのブレスロー腫瘍の厚み (TT) の中位値は,パンデミックフェーズ (1.0-1.1mm) にわたって一貫したままでした.
- 調整された分析は,パンデミック中またはその後,TTの有意な増加を示さなかった.
- 流行後のAJCCステージ0/Tisプレゼンテーションの有意な減少が観察されました (OR 0.24),遅れた診断または変更された紹介パターンを示唆します.
結論:
- この入院患者コホートでは,調整後のCOVID-19パンデミックは,より厚い侵入性メラノーマと関連していなかった.
- 流行後の早期 (0/Tis) メラノーマの診断の持続的な減少は,医療の求人または紹介プロセスにおける継続的な障害を示しています.
- マクロスコーピーの腫瘍の大きさは探索的な増加を示しましたが,データ制限と潜在的なドキュメント効果のために慎重に解釈する必要があります.
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