脳血管撮影によって誘発された内皮および組織病理学的変異の基礎となる細胞機構
Zülfikar Özgür Ertuğrul1, Mehmet Cudi Tuncer2, Mehmet Uğur Karabat3
1Department of Radiology, Gazi Yaşargil Training and Research Hospital, University of Health Sciences, Diyarbakır 21090, Turkey.
Journal of clinical medicine
|February 13, 2026
まとめ
脳血管撮影は,酸化ストレスと炎症によって血管にダメージを与える可能性があります. これらの効果を理解することは,手続の安全性と脳血管疾患治療における患者の結果の改善の鍵です.
科学分野:
- 神経科学は神経科学である.
- 血管生物学 血管生物学
- 病理学 パトロジー
背景:
- 脳血管図は,脳血管疾患の診断と治療に不可欠です.
- 血管の完全性や細胞の恒常性に対するその影響は,徹底的な調査を必要とします.
研究 の 目的:
- 脳血管撮影による内皮および組織病理学的変化を体系的に検討する.
- 酸化ストレス,炎症,内皮機能不全,血脳障壁の破壊に焦点を当てます.
主な方法:
- PRISMA 2020のガイドラインに沿った体系的なレビュー.
- 検索したPubMed,Scopus,Web of Science (1981-2025) について
- 定性合成のための200件の研究が含まれています.
主要な成果:
- 脳血管撮影は,機械的およびコントラスト媒介的効果によって,内皮/微血管の損傷を引き起こします.
- コントラスト剤は反応性酸素種を増やし,酸化窒素を弱め,炎症を活性化します (NF-κB).
- 組織病理学では,内皮損傷,アポトーシス,マイクロトロンブ,および血脳障壁の障害が,併発性疾患によって悪化することを示しています.
結論:
- 脳血管撮影は,主に酸化および炎症経路を通じて,内皮機能障害と血管損傷を誘導します.
- コントラスト剤やテクニックを最適化し,保護戦略を使用することで,被害を軽減することができます.
- バイオマーカーとアンジオグラフィーによる内皮損傷に対する介入に関するさらなる研究が必要である.
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