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Updated: Feb 14, 2026

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集団ベースのPBPKから個別化された仮想双子へ:臨床的検証と医学における応用

Marta Gonçalves1,2, Pedro Barata3,4,5, Nuno Vale1,2,6

  • 1PerMed Research Group, RISE-Health, Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal.

Journal of clinical medicine
|February 13, 2026
PubMed
まとめ

生理学に基づく薬動力学 (PBPK) モデルは,パーソナライズされた医療のために仮想双子 (VTs) に移行しています. 個々の患者データを組み込むことは,薬物投与の予測を向上させ,精密医学のための集団レベルの分析を超越します.

キーワード:
PBPKK PBPKとはクリニカル・バリデーションモデルのパフォーマンスモデルです.パーソナライズされた医療

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