パテント・フォアメン・オヴァーレは,心房細動・アブレーション患者における左心房圧に影響を与えない
Marek Kiliszek1, Marcin Wańczuk1, Beata Uziębło-Życzkowska1
1Department of Cardiology and Internal Diseases, Military Institute of Medicine-National Research Institute, 04-141 Warsaw, Poland.
Journal of clinical medicine
|February 13, 2026
まとめ
パテント・フォアメン・オヴァーレ (PFO) は,心房細動 (AF) の患者の左心房圧を下げない. この研究では,PFOの存在にもかかわらず,左心房圧の有意な差は認められなかった.
科学分野:
- 心臓病学 心臓病学
- 心臓電気生理学 心臓電気生理学
- エコーカルディオグラフィー エコーカルディオグラフィー
背景:
- 左心房圧 (LAP) の上昇は,左心房のダイアストリック機能不全のマーカーです.
- 左から右のシャントを備えた patent foramen ovale (PFO) は,潜在的にLAPを減らす可能性があります.
- 心房細動 (AF) 患者におけるPFOとLAPの関係を調査することは極めて重要です.
研究 の 目的:
- AF切除を施された患者でPFOの存在が低いLAPと関連しているかどうかを判断する.
- この特定の患者コホートにおけるPFOの左心房血動力学への影響を分析する.
主な方法:
- AF除去 (2019-2023) を受けた409人の患者の遡及的分析.
- PFOの存在は,アブレーション前に,食道横断エコーカルディオグラフィで評価される.
- LAPのトランセプト後パンクチャーの直接的処置内測定.
主要な成果:
- 409人の患者のうち85人 (20.8%) がPFOを患っており,ベースラインの特徴はグループ間で類似していました.
- PFOとPFOのない患者の間で,平均LAPの有意な差は観察されなかった (p=0.36).
- PFOの状態に関係なく,患者の34.4%に心不全歴がありました.
結論:
- AF除去手術を受けた患者の20%以上がPFOを持っています.
- PFOの存在は,AF患者で直接測定されたLAPを有意に変化させません.
- PFOは,この集団における心不全のより低い罹患率と関連していません.
関連する概念動画
ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias
611
Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...
611
Amyloid Fibrils
12.1K
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
12.1K
Amyloid Fibrils
6.5K
6.5K
Role of Affect in Interpersonal Attraction
239
Affect plays a crucial role in shaping interpersonal evaluations and perceptions. Emotions influence how individuals judge and respond to others, often determining whether interactions are viewed positively or negatively. This effect can manifest directly through interactions with the person in question or indirectly via associations with unrelated emotional experiences.Direct Effects of Affect on AttractionAffect directly influences interpersonal attraction when a person’s behavior...
239
The Influence of Affect on Cognition
305
Positive affect significantly influences cognitive processes, including evaluation, memory, creativity, and social judgments. Compared to negative affect, positive emotional states promote more favorable interpretations of stimuli, cognitive flexibility, and heuristic processing. These effects highlight emotions' powerful role in shaping how individuals perceive, remember, and interact with the world.Influence on Evaluation and AttributionWhen individuals experience positive affect, they are...
305
The Influence of Cognition on Affect
232
Cognition plays a pivotal role in shaping emotional experiences, as demonstrated by Schachter and Singer’s two-factor theory of emotion. According to this model, emotion arises from a combination of physiological arousal and cognitive interpretation. The body’s physiological response to stimuli is ambiguous and only gains emotional significance through cognitive labeling. For instance, an increased heart rate and adrenaline surge while standing near an attractive person may be...
232


