排他的授乳は,出生体重が非常に低い早産児のビタミンBの適切な状態を保証していません
Anne-Lise Bjørke-Monsen1,2, Ingrid Kristin Torsvik2, Mariann Haavik Lysfjord Bentsen2
1Laboratory of Medical Biochemistry, Førde Hospital Trust, 6807 Førde, Norway.
Nutrients
|February 13, 2026
まとめ
VLBWの早産の乳幼児の専用授乳は,適切なビタミンBを供給しない可能性があります. 補給と定期的なモニタリングは,乳児の最適な発達と成長に不可欠です.
科学分野:
- 小児の栄養について
- 微量栄養素代謝について
- 新生児の健康について
背景:
- VLBWの早産の乳児には,母乳のみの授乳が推奨されています.
- ビタミンBは,DNAメチル化を含む乳児の発達に不可欠です.
- この研究では,母乳と配方乳で授乳されたVLBWの乳児のBビタミン状態が評価されました.
研究 の 目的:
- VLBWの乳児におけるBビタミン (コバラミン,葉酸,B6,B2) の状態を比較するために,母乳のみを母乳のみで授乳した乳児と,配粉乳のみを母乳のみで授乳した乳児を比較する.
- 最初の6ヶ月で母乳育児から摂取されるビタミンBの十分さを評価するために,年齢を修正しました.
- 潜在的欠陥を特定し,VLBWの乳児に対する栄養上の勧告を伝える.
主な方法:
- ビタミンB12,葉酸,B6 (PLP),B2レベル,およびVLBWの乳児における代謝マーカー (tHcy,MMA) を測定した.
- 幼児は,受精期,2,6,12ヶ月で年齢を修正して評価されました.
- 哺乳乳類のみを母乳で授乳した乳児と,配粉を母乳で授乳した乳児の栄養状態の比較.
主要な成果:
- 哺乳乳のみを摂取した乳児は,配方栄養を摂取した乳児と比較して,コバラミン,PLP,リボフラビン濃度が低かった.
- 授乳乳児の80%は,最初の6ヶ月間にコバラミン欠乏症 (tHcy ≥6.5μmol/L) の兆候を示した.
- すべての乳児の3〜9%が1つまたは複数のビタミンBの欠乏症を示し,母乳で育った乳児ではより頻繁に発生しました.
結論:
- 適切なマルチビタミンサプリメントなしで,母乳のみの授乳だけでは,VLBWの乳児では十分なBビタミン状態を保証できません.
- 現在,VLBWの乳児に対する栄養上の推奨事項は,微量栄養素摂取量に関する改善を必要としています.
- ビタミン状態の定期的なモニタリングは,早産VLBWの赤ちゃんのフォローアップケアに不可欠です.
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