腸内微生物群と化学療法を受けている大腸がん患者の栄養プロファイル: 縦断型パイロット研究
Claire Han1,2, Daniel Spakowicz3, Diane Von Ah1,2
1Center for Healthy Aging, Self-Management and Complex Care, College of Nursing, The Ohio State University, Newton Hall, 1585 Neil Avenue, Columbus, OH 43210, USA.
Nutrients
|February 13, 2026
まとめ
化学療法は,結腸がん患者の食事の質と腸内微生物群の多様性に悪影響を及ぼします. より質の高い食生活は,これらの悪影響から保護し,治療中に栄養と腸の健康との関連を示唆する可能性があります.
科学分野:
- 腫瘍学 腫瘍学
- マイクロバイオーム研究
- 栄養科学とは,栄養科学である.
背景:
- 栄養と腸内微生物群は,化学療法を受けている結腸がん患者の治療耐性と回復に不可欠です.
- この試験試験では,化学療法中の食事の質と糞便の微生物群の変化を調査しています.
研究 の 目的:
- 化学療法の6ヶ月間にわたる食事の質と糞便の微生物群の変化を調べる.
- 食事の質と腸内微生物群の多様性と分類の間の縦断的な関連性を評価する.
主な方法:
- ステージII-IIIの結腸癌で,5-フッ素ウラシルベースの化学療法を受けている48人の成人を評価した.
- 食事の質は,3日間の食事リコールから得られた健康的な食事指数 (HEI) を使用して測定されました.
- 糞便のサンプルは,微生物の多様性および分類的組成分析のための16S rRNA配列を解析した.
主要な成果:
- 化学療法中に食事の質が低下し,繊維,果物,野菜,全粒穀物の摂取量が減少した.
- 腸内微生物のアルファ多様性が減少し,フィラ (アクティノバクテリオタ減少;バクテリオタ増加,プロテオバクテリア増加) と特定の属 (ストレプトコッカス減少,エシェリキア増加) が変化した.
- 基準値より高い食事の質と改善は,より大きな微生物の多様性とより低いプロテオバクテリアの豊富さに関連しており,有益な遺伝子の肯定的な関連性がありました.
結論:
- 化学療法は,分類学的変化とともに,食事の質と腸内微生物の多様性の低下と関連しています.
- より高い食事の質は,化学療法によって引き起こされる微生物の破壊から保護するように見えますが,これは双方向的な関係を示しています.
- 栄養および微生物群に焦点を当てた介入は,化学療法を受けている大腸がん患者のさらなる調査を正当化します.
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