食中の栄養素,腸内微生物群,心臓機能:代謝メカニズムから臨床応用へ
Lucia Scisciola1, Manuela Giovanna Basilicata1, Marta Belmonte2,3
1Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", P.zza L. Miraglia, 2, 80138 Naples, Italy.
Nutrients
|February 13, 2026
まとめ
腸内微生物は,心臓の健康に影響を与える代謝物を生成します. ダイエットはこれらの代謝産物に影響を及ぼし,心臓血管の保護と治療戦略の新たな道を開きます.
科学分野:
- 心血管研究 循環器科の研究
- マイクロバイオーム科学 マイクロバイオーム科学
- メタボロミクスとは
背景:
- 心臓は,様々な基板から一貫したエネルギーを必要とします.
- トリメチラミンN酸化物 (TMAO) と短鎖脂肪酸 (SCFA) を含む腸内微生物群由来代謝物は,心臓の代謝と機能に影響します.
- これらの代謝産物と心血管疾患の間には関連性があるが,因果関係に関する証拠は限られている.
研究 の 目的:
- 微生物群に由来する代謝産物と心血管疾患に関する証拠をレビューし統合する.
- これらの代謝産物の心臓機能と結果における役割を調査する.
- 腸心軸を標的とした食事介入の可能性を評価する.
主な方法:
- 臨床前,臨床,メンデルのランダム化研究に関する包括的なナラティブレビュー (PubMed 2010-2025).
- ダイエット試験および介入試験のデータを含む.
- 腸内微生物群の代謝産物と心血管疾患に関する発見の統合.
主要な成果:
- 腸内代謝物は,ミトコンドリア,炎症,免疫,酸化,内皮,血小板経路を調節する.
- TMAOとフェニルアセチルグルタミン (PAGln) の値上昇は,有害な心血管疾患との関連があります.
- SCFAとインドル誘導体は,保護効果を提供することができるが,結果は異質である;食事は代謝産物プロフィールに大きく影響する.
結論:
- ダイエット・マイクロバイオタ・メタボライト軸は,栄養と心血管の健康を結びつける重要な経路です.
- 臨床翻訳には,さらなる大規模なランダム化研究とマルチオミックスのアプローチが必要である.
- 微生物代謝の食事による調節は,心臓代謝の保護のための有望な戦略です.
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