腸内細菌の安全性と耐受性Phascolarctobacterium faecium DSM 3289090 DSM 3289090 腸内細菌の安全性と耐受性Phascolarctobacterium faecium DSM
Maria Tamayo1, Veronica Tolosa-Enguis1, Blanca Alabadi2,3
1Microbiome Innovation in Nutrition and Health Research Unit (INNOBIOME), Institute of Agrochemistry and Food Technology, Spanish National Research Council (IATA-CSIC), 46980 Valencia, Spain.
Nutrients
|February 13, 2026
まとめ
Phascolarctobacterium faecium DSM 32890はラットとヒトに安全でよく耐える. この腸内細菌は,代謝健康における将来の有効性研究の可能性を示しています.
科学分野:
- 微生物学 微生物学とは
- 人体健康 人体健康 人体健康
- 毒理学 毒理学 毒理学
背景:
- Phascolarctobacterium faecium (P. faecium) は,正常体重と関連している腸内細菌である.
- P. faecium DSM 32890菌株は,肥満モデルにおける代謝および免疫機能の改善に有望であることが示されています.
研究 の 目的:
- P. faecium DSM 32890.の安全性と耐受性を評価するために
- この菌株を臨床前 (ネズミ) とヒトでの試験試験で評価する.
主な方法:
- ウィスターマウスの28日間の経口毒性研究.
- 20人の参加者が参加した15日間のパイロットヒト試験で,さまざまな健康マーカーと耐受性を評価しました.
主要な成果:
- ラットでは複数の評価マーカーで有害な影響は見られなかった.
- ヒトの参加者は安全性に関する懸念を示さなかった. 肥満の個人は浮気や吐き気が減ったと報告した.
結論:
- P. faecium DSM 32890は,ラットとヒトの両方で安全でよく耐受されます.
- これらの発見は,菌株の潜在的な有効性に関するさらなる研究を支援しています.
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