ディスビオシスから苦悩へ:トラウマ関連疾患における腸-脳接続

Giuseppe Marano^1,2, Luca Lo Giudice^1,2, Elettra Specogna^1,2

¹Department of Neuroscience, Head-Neck and Chest, Section of Psychiatry, Fondazione Policlinico Universi-Tario Agostino Gemelli IRCCS, Largo Agostino Gemelli 8, 00168 Rome, Italy.

Nutrients

|February 13, 2026

まとめ

腸内微生物群の変化は,心的外傷後ストレス障害 (PTSD) の症状と関連しており,腸-脳軸に影響を及ぼします. 腸を標的とした介入は,PTSDに対する新しい治療の機会を提供することができる.

科学分野:

神経科学は神経科学である.
微生物学微生物学とは
精神科医は精神病を患っている.

背景:

トラウマ後ストレス障害 (PTSD) は,複雑な心理的,神経生物学的,および全身的生理学的要因を含む.
腸-脳軸は,ストレス反応,感情の調節,トラウマ関連疾患における神経炎症において重要な役割を果たします.

研究の目的:

PTSDにおける腸内微生物群と中枢神経系の相互作用に関する現在の文献をレビューする.
潜在的メカニズムと,PTSDの腸-脳軸を標的とした治療戦略を強調する.

主な方法:

PubMed,Scopus,およびWeb of Scienceの包括的な文献検索. 科学のウェブについて.
過去20年間の臨床,前臨床,翻訳研究に焦点を当てた.
神経内分泌/免疫経路に対する微生物群の影響と腸-脳軸の介入を強調する.

主要な成果:

腸の機能不全と,過透性の増加は,PTSDの症状と相関しています.
そのメカニズムには,下垂体・下垂体・腎上腺 (HPA) 軸の調節不全,神経炎症,神経伝達物質の生産の変化などが含まれる.
臨床前データは,早期のストレス,トラウマ,腸内微生物群との双方向的な関連性を示しています. 臨床前データは,プロバイオティクス,ダイエット,精神生物学的薬の利点を示唆しています.

結論:

腸-脳軸は,PTSDの病理生理学を理解するための有望な枠組みを提供します.
腸内微生物群をターゲットにすることは,PTSDの新たな予防および治療の可能性を提示します.
発見を検証し,臨床応用を導くためにさらなる研究が必要である.

キーワード:

HPA軸は,HPA軸と一致しています.PTSDとは,PTSDとは,PTSDとは,PTSDとは,PTSDとは,ディスバイオシス (Dysbiosis) とは腸脳軸腸脳軸メンタルヘルスメンタルヘルス微生物群 (microbiota) とは神経炎症による神経炎症です.サイコバイオティクスは,トラウマ・トラウマトラウマ・トラウマトラウマ・トラウマトラウマ・トラウマ

さらに関連する動画

11:14

Acute Brain Trauma in Mice Followed By Longitudinal Two-photon Imaging

Published on: April 6, 2014

13.0K

$Pseudofracture: An Acute Peripheral Tissue Trauma Model$ 10:08

Pseudofracture: An Acute Peripheral Tissue Trauma Model

Published on: April 18, 2011

15.2K

関連する概念動画

02:18

Intrinsically Disordered Proteins

19.6K

Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...

19.6K

01:23

Dietary Connections

62.2K

In biological systems, most metabolic pathways are interconnected. The cellular respiration processes that convert glucose to ATP—such as glycolysis, pyruvate oxidation, and the citric acid cycle—tie into those that break down other organic compounds. As a result, various foods—from apples to cheese to guacamole—end up as ATP. In addition to carbohydrates, food also contains proteins and lipids—such as cholesterol and fats. All of these organic compounds are used...

62.2K

01:11

Introduction to Connective Tissues

15.4K

Connective tissues are one of the four main tissue types in humans that are extensively present in the body. They are characterized by cells embedded in an extracellular matrix (ECM) composed of a ground substance and three main types of protein fibers— collagen, elastic, and reticular fibers. The ground substance of connective tissues can range from a watery and jelly-like consistency to mineralized and hard. The wide variety of cells in the connective tissues include fibroblasts,...

15.4K

01:30

Classification of Connective Tissues

16.4K

The connective tissues have different properties and functions in the human body. They are broadly categorized into proper, supporting, or fluid connective tissues.
Connective Tissue Proper
Connective tissue proper is the most abundant class of connective tissues. As its name implies, it predominantly connects different tissues in the body. Depending on the cell types, ground substance, viscosity, and fiber types in the ECM, connective tissue proper is further categorized into loose and dense....

16.4K

01:20

Embryonic Connective Tissues

6.6K

During early development, the embryo forms two types of connective tissues— the mesenchyme and mucoid connective tissue.
The mesenchyme is the first connective tissue that emerges in the developing embryo. It consists of loosely arranged multipotent mesenchymal cells and reticular fibers in the extracellular matrix. This loose arrangement allows easy migration of cells, which is essential for germ layer positioning, patterning, and organ morphogenesis during embryonic development.

6.6K

01:13

Dense Connective Tissue

12.4K

Dense connective tissue contains more collagen fibers than loose connective tissue. As a consequence, it displays greater resistance to stretching. There are two major categories of dense connective tissue— regular and irregular.
Dense Regular Connective Tissue
In dense regular connective tissue, fibers are arranged parallel to each other, enhancing its tensile strength and resistance to stretching in the direction of the fiber orientations. Ligaments and tendons are made of dense regular...