関連する実験動画

Updated: Feb 14, 2026

High Fat Diet Feeding and High Throughput Triacylglyceride Assay in Drosophila Melanogaster
08:28

High Fat Diet Feeding and High Throughput Triacylglyceride Assay in Drosophila Melanogaster

Published on: September 13, 2017

12.0K

肝臓のUGT2B媒介のテストステロンクリアランスは,高脂肪食誘発のMASLDにおける脂質蓄積を促進する

Liping Zhou1, Yingzhuan Zheng2, Yujie Qiao1

  • 1Obesity and Metabolic Diseases Research Center, Department of Medical Laboratory Technology, School of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, China.

Nutrients
|February 13, 2026
PubMed
まとめ

男性における代謝機能不全関連ステアトス性肝疾患 (MASLD) は,肝臓のコレステロールとテストステロンの変化を伴う. UGT2B酵素のアップレギュレーションは,テストステロンの分解を加速し,低テストステロンのレベルを説明し,UGT2Bを治療目標として示唆しています.

キーワード:
マスルド (MASLD) とはUGT2B ユニットコレステロール コレステロール コレステロール脂肪が多いダイエットテストステロンのテストステロンのテストステロンのテストステロンのテストステロンは,

さらに関連する動画

Vinyl Chloride and High-Fat Diet as a Model of Environment and Obesity Interaction09:15

Vinyl Chloride and High-Fat Diet as a Model of Environment and Obesity Interaction

Published on: January 12, 2020

6.8K
Rapid Model to Evaluate the Anti-Obesity Potential of a Combination of Syzygium aromaticum Clove and Cuminun cyminum Cumin on C57BL6/j Mice Fed High-Fat Diet13:09

Rapid Model to Evaluate the Anti-Obesity Potential of a Combination of Syzygium aromaticum Clove and Cuminun cyminum Cumin on C57BL6/j Mice Fed High-Fat Diet

Published on: July 31, 2021

4.1K

関連する概念動画

Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance01:07

Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance

Drug transporters are critical in drug absorption, distribution, and excretion processes. They should be included in physiological-based pharmacokinetic (PBPK) models, which help predict human drug disposition. However, predicting this is challenging during drug development, especially when liver transport is involved. However, with a realistic representation of body transport processes, an accurate model may be possible.
A recent model describes pravastatin's hepatobiliary excretion,...
304
Hepatic Drug Clearance: Restrictive and Nonrestrictive Clearance01:09

Hepatic Drug Clearance: Restrictive and Nonrestrictive Clearance

Hepatic clearance refers to the volume of blood cleared of a drug by the liver per unit of time. It plays a crucial role in drug metabolism and elimination. While hepatic clearance is commonly estimated by subtracting renal clearance from total body clearance, other pathways, such as pulmonary or biliary clearance, may also contribute. However, these pathways are generally less significant than hepatic and renal clearance.
Most drugs undergo restrictive clearance, which is proportional to the...
550
Hepatic Drug Clearance: Role of Transporters01:14

Hepatic Drug Clearance: Role of Transporters

In the liver and bile canaliculi, influx and efflux transporters modification can influence intrinsic clearance. Transporters play a significant role in moving drugs within liver cells. Elaborate models, such as the Biopharmaceutical Classification System (BCS), are essential to relate transporters to drug disposition. This system categorizes drugs into four classes based on solubility and permeability, providing insights into elimination routes and the effects of transporters following oral...
312
Hepatic Drug Clearance: Effect of Protein Binding01:09

Hepatic Drug Clearance: Effect of Protein Binding

Hepatic clearance is influenced by protein binding based on the drug's extraction ratio. Drugs with high extraction ratios are considered flow-limited and remain unaffected by protein binding during hepatic clearance. On the other hand, drugs with low extraction ratios may be impacted by plasma protein binding, although the extent of this influence depends on the fraction of the drug bound.
For low-extraction-ratio drugs that are less than 80% protein-bound, minor changes in protein binding...
566
What are Lipids?01:38

What are Lipids?

Overview
221.2K
Lipid Digestion01:06

Lipid Digestion

Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.
99.9K