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Updated: Feb 14, 2026

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

17.6K

GluN1-GluN2A受容体を標的とした潜在的コンピューティングヒットのDe Novo世代ベースの設計

Yibo Liu1,2, Zhijiang Yang2, Yixuan Guo2

  • 1School of Chemical and Material Engineering, Jiangnan University, Wuxi 214000, China.

Molecules (Basel, Switzerland)
|February 13, 2026
PubMed
まとめ

研究者らは,中枢神経系 (CNS) の疾患に対するGluN1-GluN2A受容体を標的とした新薬候補を開発した. 3つの化合物は (S) -ケタミンよりも高い結合親和性を示し,受容体の活性が抑制され,うつ病の治療の可能性を示した.

キーワード:
GluN1-GluN2A受容体アンタゴニストde novo分子生成について電気生理学 電気生理学動作シミュレーションのメカニズム有機合成による有機合成です.仮想スクリーニングです.

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