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Updated: Feb 14, 2026

Culturing Microglia from the Neonatal and Adult Central Nervous System
11:28

Culturing Microglia from the Neonatal and Adult Central Nervous System

Published on: August 9, 2013

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新生児のクロミプラミン曝露は,成人ラットにおけるエピディジマのセロトニンシグナル伝達とプログラム精子機能不全を妨害する

Herlinda Bonilla-Jaime1, Ofelia Limón-Morales1, Ernesto Rodríguez-Tobón2

  • 1Laboratorio de Psicobiológia Conductual, Departamento de Biología de la Reproducción, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City 09340, Mexico.

International journal of molecular sciences
|February 13, 2026
PubMed
まとめ

選択的セロトニン再吸収阻害剤 (SSRI) であるクロミプラミン (CMI) に新生児の被曝は, epididymis のセロトニンシステムを変化させることで,永久に精子の質を害します. この初期のSSRI曝露は,5-HTホメオスタシスを破壊し,長期的な生殖機能障害につながります.

キーワード:
クロミプラミン (clomipramine) とはミトコンドリアの活動反応性酸素種に反応する.セロトニン・セロトニンとはセロトニンのトランスポーターであるセロトニントランスポーター.

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