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Updated: Feb 14, 2026

Determining Binding Affinity KD of Radiolabeled Antibodies to Immobilized Antigens
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抗体-抗原結合の原動力を理解する方向へ

Omeir Khan1, Marcus Kankkunen2, Michel Shaker2

  • 1Department of Chemistry Engineering Boston University Boston, MA, USA.

Biophysical journal
|February 13, 2026
PubMed
まとめ

抗体-抗原相互作用は,ホットスポットに富んだ抗体パラトープによって引き起こされます. TrpやTyrのような芳香的残留物は,結合の安定性にとって重要なものであり,ホットスポットは,結合していない場合でも,しばしば持続します.

キーワード:
ホットスポットマッピング抗体-抗原インターフェイス断片の位置を決定する.

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