関連する実験動画

Updated: Feb 14, 2026

Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin
10:21

Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin

Published on: September 12, 2019

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ANCA関連性血管炎における補足系:メカニズム的洞察,治療的視野,および満たされていない臨床的ニーズ

Kehinde Sunmboye1,2, Pauline Millan1

  • 1Rheumatology, University Hospitals of Leicester NHS Trust, Leicester, GBR, Leicester, England, UK.

Immunity, inflammation and disease
|February 13, 2026
PubMed
まとめ

コンプリメントの活性化は,ANCA関連血管炎 (AAV) の炎症を強める. アバコパンのような治療法で補充をターゲットにすることは有望ですが,よりよい再発予測とより安全な治療のためにさらなる研究が必要です.

キーワード:
ANCAに関連した血管炎C5a受容体アンタゴニスト代替的な経路がある.コンプリメントのアクティベーションです.コンプリメンタル・ターゲティング・セラピー

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A Contusive Model of Unilateral Cervical Spinal Cord Injury Using the Infinite Horizon Impactor07:28

A Contusive Model of Unilateral Cervical Spinal Cord Injury Using the Infinite Horizon Impactor

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Complement System01:27

Complement System

The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
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Complementation Tests

A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
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No object with a finite mass can travel faster than the speed of light in a vacuum. This fact has an interesting consequence in the domain of extremely high gravitational fields.
The minimum speed required to launch a projectile from the surface of an object to which it is gravitationally bound so that it eventually escapes the object’s gravitational field is called the escape velocity. The escape velocity is independent of the mass of the object. Merging the idea of escape...
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The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...
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Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least...
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