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関連する概念動画

Chromatin Packaging02:21

Chromatin Packaging

22.4K
Each human somatic cell contains 6 billion base-pairs of DNA. Each base-pair is 0.34 nm long, which means that each diploid cell contains a staggering 2 meters of DNA. How is such a long DNA strand packed inside a nucleus measuring only 10 - 20 microns in diameter? 
The chromatin
In combination with specialized DNA binding protein called Histones, the DNA double helix forms a compact DNA: protein complex called chromatin. The chromatin itself is further compacted into higher-order...
22.4K
Chromatin Packaging01:32

Chromatin Packaging

19.6K
Each human somatic cell contains 6 billion base pairs of DNA. Each base pair is 0.34 nm long, meaning each diploid cell contains a staggering 2 meters of DNA. This long DNA strand is packed inside a nucleus measuring only 10-20 microns in diameter with the help of specialized DNA-binding proteins called histones. Together they form a compact DNA-protein complex called chromatin. The chromatin is further compacted into higher-order structures. The highest level of compaction is achieved during...
19.6K
Spreading of Chromatin Modifications02:25

Spreading of Chromatin Modifications

9.5K
The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer...
9.5K
Chromatin Position Affects Gene Expression02:35

Chromatin Position Affects Gene Expression

24.9K
Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
24.9K
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

7.6K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
7.6K
Predicting Molecular Geometry02:27

Predicting Molecular Geometry

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VSEPR Theory for Determination of Electron Pair Geometries
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ナノループ:クロマチンのループ予測のためのナノ孔配列を活用したディープラーニング・フレームワーク.

Wenjie Huang1, Li Tang1, Matthew C Hill2,3

  • 1School of Computer Science and Engineering, Central South University, Changsha, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|February 13, 2026
PubMed
まとめ

NanoLoopは,ナノポールのシーケンシングデータを用いて,ゲノム全体のクロマチンの相互作用を予測します. このフレームワークは,クロマチンのループと3Dゲノム組織に影響を与えるメチル化パターンを明らかにし,遺伝子調節に関する新しい洞察を提供します.

キーワード:
DNAメチレーションによるDNAメチレーションクロマチンループのクロマチンは,巻き込みニューラルネットワーク (CNN)エピジェネティック・レグレーションナノポーアのシーケンシング

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Sequencing of mRNA from Whole Blood using Nanopore Sequencing
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Last Updated: Feb 14, 2026

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09:34

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Sequencing of mRNA from Whole Blood using Nanopore Sequencing
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科学分野:

  • ゲノミクスゲノミクスとは
  • エピジェネティクス エピジェネティクス
  • バイオインフォマティックス

背景:

  • クロマチンのループは,遺伝子調節と3Dゲノム構造に不可欠です.
  • ナノ孔配列化は,同時にDNA配列とメチレーション検出を提供します.
  • 3Dゲノム組織を理解することは,細胞のホメオスタシスの鍵です.

研究 の 目的:

  • ナノポールのデータからゲノム全体のクロマチンの相互作用を予測するための最初のアルゴリズムフレームワークであるNanoLoopを紹介する.
  • 3Dゲノム組織におけるDNAメチル化パターンの役割を調査する.
  • 新しいクロマチンのループとその調節関係を発見する.

主な方法:

  • ナノポールのシーケンシングデータを活用したアルゴリズムフレームワークであるNanoLoopを開発した.
  • NanoLoopを4つのヒトリンパ芽細胞細胞系に適用しました.
  • クロマチンのループアンカーでメチル化パターンを分析した.

主要な成果:

  • NanoLoopは優れた予測性能とクロス・セル・ライン・ジェネラライゼーションを達成しました.
  • ループアンカーで4つの異なるメチル化パターンを特定し,ヒストンの改変とループタイプに影響を与えました.
  • 以前は特徴づけられていなかった長距離クロマチンのループが発見されました.

結論:

  • NanoLoopは,ナノポールのデータからクロマチンの相互作用を効果的に予測します.
  • DNAメチル化パターンは,3Dゲノム組織とクロマチンのループ形成と関連しています.
  • 3Dゲノムの表遺伝学的調節に関する新しい洞察を提供します.