関連する実験動画

Updated: Feb 14, 2026

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

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単一ミトコンドリアATPプロフィーリングは,がんにおける標的型OXPHOS依存性の発見を導く

Xu Xiao1, Cheng Lu1, Hao Chen1

  • 1Department of Chemical Biology, MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Fujian Key Laboratory of Chemical Biology (Xiamen University), State Key Laboratory of Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|February 13, 2026
PubMed
まとめ

癌細胞は正常細胞よりもミトコンドリアのATPレベルが高く,これは新しいナノフロー細胞測定法によって明らかになった. このプラットフォームは,ミトコンドリア代謝阻害剤をスクリーニングすることにより,標的治療の開発に役立ちます.

キーワード:
癌の脆弱性 がんに対する脆弱性ミトコンドリア ATPミトコンドリアの代謝精密がん療法とは,精密がん療法です.単一オーガネルの分析

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The bonds of adenosine triphosphate (ATP) can be broken through the addition of water, releasing one or two phosphate groups in an exergonic process called hydrolysis. This reaction liberates the energy in the bonds for use in the cell—for instance, to synthesize proteins from amino acids.
If one phosphate group is removed, a molecule of ADP—adenosine diphosphate—remains, along with inorganic phosphate. ADP can be further hydrolyzed to AMP—adenosine...
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There are several types of targeted therapies against...
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Adenosine triphosphate (ATP) is a critical molecule that functions as the main energy carrier in cells. Structurally, ATP consists of an adenosine molecule—comprising adenine and ribose—bonded to three phosphate groups. The high-energy bonds between these phosphate groups store significant amounts of potential energy. This energy is released during hydrolysis, wherein ATP is converted to adenosine diphosphate (ADP) or adenosine monophosphate (AMP), driving a variety of essential...
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