双極性障害の患者と健康な対照群の髪の毛に化学元素のプロファイリングを行いました
Hiba Zannadeh1, Monica Aas2, Vishnu Priya Sampath1
1Department of Medical Neurobiology, Institute for Medical Research Israel-Canada, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Frontiers in physiology
|February 13, 2026
まとめ
双極性障害 (BD) は,頭皮の髪の毛に含まれる特定の化学元素のレベルの変化を伴う可能性があります. 研究者らは,BD患者でアルミニウム,銅,ニッケル,タリウムの値が高く,ニッケルが疾患の重症度と相関していることを発見しました.
科学分野:
- 神経科学は神経科学である.
- バイオケミストリー バイオケミストリー
- 環境衛生 環境衛生 環境衛生
背景:
- 双極性障害 (BD) は,不明な分子メカニズムを持つ重度の気分障害です.
- Na+,K+-ATPaseメタルプロテインは元素と相互作用し,潜在的にBDに影響を与えます.
- 以前の研究では,BD患者の脳の領域における元素濃度の変化が認められた.
研究 の 目的:
- 頭皮の髪に含まれる化学元素の濃度が,BDの患者と健康な対照群の間で異なっているかどうかを調査する.
- BDの病因と進行の潜在的バイオマーカーを探求する.
主な方法:
- 誘導結合プラズマ質量スペクトロメトリー (ICP-MS) を用いて25の化学元素を分析した.
- 30人のBD患者と30人の対照群の頭皮毛サンプルを分析した.
主要な成果:
- アルミニウム (Al),銅 (Cu),ニッケル (Ni),タリウム (Tl) の濃度が高く,BD患者の髪の毛に検出されました.
- 髪のニッケル (Ni) 濃度は双極性障害の重症度と相関しています.
結論:
- 頭皮の髪の化学元素の変化は,双極性障害の病因学や進行に関連している可能性があります.
- これらの発見を確認するために,より大きなサンプルサイズのさらなる研究が必要です.
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