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Updated: Feb 14, 2026

A Novel Stromal Fibroblast-Modulated 3D Tumor Spheroid Model for Studying Tumor-Stroma Interaction and Drug Discovery
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脂質リモデリングとフェロプトーシスは,フォスファディチルコリン媒介の腫瘍-ストロマクロストックにおける

Manikandan Vani Raju1, Meenakshi Kaniyur Chandrasekaran1, Lavanya Loganathan2

  • 1Department of Biochemistry, Karpagam Academy of Higher Education, Coimbatore, Tamil Nadu, India.

Frontiers in molecular biosciences
|February 13, 2026
PubMed
まとめ

フォスファディチルコリン-フェロプトーシス軸は,細胞代謝と腫瘍ストロマの相互作用をリンクし,がんの進行と治療抵抗に影響を与える. この軸をターゲットにすることで,がんに対する新しい組み合わせ治療のための有望な戦略が生まれます.

キーワード:
プーファ (PUFA) とはフェロプトーシス (ferroptosis) とは脂質過酸化による脂質過酸化フォスファディチルコレイン (Phosphatidylcholine) が含まれる.腫瘍のマイクロ環境

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