ラクトバシルスによって発酵された大豆乳の抗食品アレルギー活性 in vitro
Xinlei Xia1,2,3, Ping Tang1,2,3, Jing Bai1,2,3
1State Key Laboratory of Food Science and Resources, Nanchang University, Nanjing Dong Lu 235, Nanchang, 330047 China.
Journal of food science and technology
|February 13, 2026
まとめ
この研究では,抗食物アレルギー特性を有する発酵大豆ミルク (FSM) が開発されました. FSM飲料は,ヒアルウロニダースを効果的に抑制し,炎症マーカーを減少させ,食物アレルギーの新しい食事の選択肢を提供しました.
科学分野:
- 食品科学 食品科学について
- 免疫学 免疫学とは
- 栄養科学とは,栄養科学である.
背景:
- 食物アレルギー (FA) は重要な健康問題であり,厳格な食事の回避が栄養素摂取に影響を与える.
- 現在のFAの管理は,アレルギーを引き起こす食品を避けることに依存しており,代替的な食事戦略が必要である.
研究 の 目的:
- 食品アレルギーに対する効果を持つ発酵大豆ミルク (FSM) 製品を開発する.
- 開発されたFSMの生物活性成分と抗アレルギー効果を評価する.
主な方法:
- Lactobacillus acidophilus と Lactobacillus plantarum の亜種を用いた大豆乳の発酵 足首 (plantarum) についてです.
- プリバイオティクスとしてフルークトオリゴサッカライド (FOS) とポリフェノールサプリメントとしてブドウシードエキス (GSE) を添加する.
- OVAによって誘発されたKU812細胞のデグラヌレーションに対するヒアルウロニダース抑制の測定とFSM介入の評価.
主要な成果:
- FSM飲料は,強力な抗アレルギー効果を示し,有意なヒアルウロニダース阻害 (最大87.35%) を示した.
- FSMは,KU812細胞のデグラヌレーションを阻害し,TNF-αやIL-6のような炎症媒介体の放出を抑制する能力を示した.
- グレープシードエキスを加えることで,Ca2+の流入が著しく抑制され,抗アレルギー特性にも貢献しました.
結論:
- 開発された発酵大豆ミルク (FG-FSM) は,強力な抗食物アレルギー特性を有しています.
- FG-FSMは,食物アレルギーのある人のための機能的な飲み物としての可能性を示しています.
- この研究は,食品アレルギーの管理のための新しい食事の代替品としてFG-FSMを提案しています.
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