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Updated: Feb 14, 2026

Author Spotlight: Developing Acetyl-Click Assay for HAT1 Inhibitor Screening
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2から1へ:アセチル-CoA合成酵素におけるCO結合を解除する.

Denise Poire1,2, Cornelius C M Bernitzky1, Mathesh Vaithiyanathan1

  • 1Freie Universität Berlin, Department of Physics, Ultrafast Dynamics in Catalysis Arnimallee 14 14195 Berlin Germany marius.horch@fu-berlin.de.

Chemical science
|February 13, 2026
PubMed
まとめ

アセチル-コア合成酵素 (ACS) は,生理学的条件下で一酸化炭素 (CO) リガンドのみを結合し,以前のモデルに異議を唱える. 先進的な分光学により,単一のCO結合部位が確認され,酵素の機能が明らかになった.

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