MASLDと肝繊維症の負担: Phenome Indiaコホートからの証拠
Meghana Arvind1, Anshul Verma1,2, Sreeshma Raj K1
1CSIR-Institute of Genomics and Integrative Biology, New Delhi, 110007, India.
The Lancet regional health. Southeast Asia
|February 13, 2026
まとめ
メタボリック機能障害に関連したステアトス性肝疾患 (MASLD) は,インドの成人の約40%に影響を与え,MASLD症例の4.1%で有意な線維症が見つかりました. これは,ターゲットを絞った介入を必要とする公衆衛生上の懸念が高まっていることを強調しています.
科学分野:
- 肝臓病理学 肝臓病理学
- 公衆衛生は公衆衛生である.
- エピデミオロジー エピデミオロジー
背景:
- メタボリック機能障害に関連するステアトス性肝疾患 (MASLD) の流行率は,インドからの限られたコミュニティベースのデータで,世界的に増加しています.
- この研究は,Phenome Indiaコホート内のMASLDと線維症の有病率を調査することによって,知識のギャップを解決します.
研究 の 目的:
- インドにおけるMASLDおよびそのサブグループの流行,分布および特徴を決定する.
- MASLDとMASLDのない個体における有意な線維症の罹患率を評価する.
主な方法:
- インドの27の都市にある37の研究室から10,267人の成人を対象とした前向きな研究です.
- トランジエント・エラストグラフィは,臨床,生化学,人体測定データとともに,肝臓ステアトーシスおよび線維症を評価するために使用されました.
- 研究集団とサブグループについて,年齢調整された罹患率を計算した.
主要な成果:
- 7764人の参加者のうち,3712人 (47.8%) がMASLDの基準を満たし,年齢調整後の罹患率は38.9%であった.
- 顕著な線維症 (LSM ≥8.2 kPa) は,MASLDの症例 (年齢調整4.1%) で,MASLD以外の症例 (1.7%) よりも一般的であった.
- 有意な線維症は,高齢者 (>60歳) や糖尿病や肥満の患者で集中しており,地域によって異なる可能性がある.
結論:
- MASLDは,調査されたインド人口の3分の1以上に影響を及ぼし,公衆衛生上の負担が大きいことを示しています.
- 観測されたサイト固有の格差は,地域固有のリスク要因と傾向に関するさらなる研究を必要とします.
- 地域社会での認知度向上と公衆衛生上の標的型介入は,インドで増加するMASLDの負担を管理する上で極めて重要です.
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