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関連する概念動画

Alternative RNA Splicing02:18

Alternative RNA Splicing

25.3K
Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
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Alternative RNA Splicing02:18

Alternative RNA Splicing

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RNA Splicing01:32

RNA Splicing

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Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
60.7K
Bacterial Transformation01:33

Bacterial Transformation

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In 1928, bacteriologist Frederick Griffith worked on a vaccine for pneumonia, which is caused by Streptococcus pneumoniae bacteria. Griffith studied two pneumonia strains in mice: one pathogenic and one non-pathogenic. Only the pathogenic strain killed host mice.
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
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Null and Alternative Hypotheses01:16

Null and Alternative Hypotheses

12.8K
The actual hypothesis testing begins by considering two hypotheses. They are termed  the null hypothesis and the alternative hypothesis. These hypotheses contain opposing viewpoints.
The null hypothesis, denoted by H0 is a statement of no difference between the variables—they are not related. This can often be considered the status quo. As  a result if you cannot accept the null, it requires some action.
The alternative hypothesis, denoted by H1 or Ha, is a claim about the...
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Chromatin Structure and RNA Splicing02:41

Chromatin Structure and RNA Splicing

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Updated: Feb 14, 2026

Identification of Alternative Splicing and Polyadenylation in RNA-seq Data
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ASPECT: トランスフォーマーによる代替スプライシングイベント分類

Sahil Thapa, Miguelangel Tamargo, Oluwatosin Oluwadare

    bioRxiv : the preprint server for biology
    |February 13, 2026
    PubMed
    まとめ
    この要約は機械生成です。

    DNABERT-2 を使用した新しいフレームワークであるASPECTは,代替スプライシングイベントを正確に分類します. この進歩は,疾患における複雑なスプライシングの理解を助け,トランスクリプトミックの多様性研究を拡大する.

    さらに関連する動画

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    Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
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    Identification of Alternative Splicing and Polyadenylation in RNA-seq Data
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    Identification of Alternative Splicing and Polyadenylation in RNA-seq Data

    Published on: June 24, 2021

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    Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
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    Published on: October 9, 2014

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    Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
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    科学分野:

    • ゲノミクスと分子生物学
    • コンピュータ生物学 コンピュータ生物学
    • バイオインフォマティックス

    背景:

    • 代替スプライシング (AS) は,タンパク質の多様性にとって極めて重要な多様なmRNA同型を生成します.
    • 機能不全のAS変種は,さまざまな疾患に関連しています.
    • 現在のASの研究は,しばしば特定のイベントタイプを無視し,限られた計算アプローチに依存しています.

    研究 の 目的:

    • 代替スプライシングイベントを分類するためのコンピューティングフレームワークを開発する.
    • スプライシングの決定における規制文脈を把握するための既存の方法の限界に対処する.
    • ASの包括的な特徴と,人間の健康と病気におけるその役割を改善する.

    主な方法:

    • アスペクト (ASPECT) を開発し,代替のスプライシングイベント分類フレームワークを開発しました.
    • バイトペアエンコーディング (BPE) トークン化によるDNABERT-2を使用しました.
    • バイナリ代替スプライシングイベントペア分類タスクの評価性能.

    主要な成果:

    • ASPECTは,AUC,F1スコア,および精度で測定された分類タスク全体で強力なパフォーマンスを示しました.
    • このフレームワークは,密接に関連したスプライシングイベントのタイプを確実に区別しました.
    • ASPECTは,TCGA BRCAがん関連スプライシングイベントに対して一貫したパフォーマンスを示し,その適用性を検証しました.

    結論:

    • ASPECTは,代替スプライシングイベントの分類のための堅牢な方法を提供します.
    • このフレームワークは,複雑なスプライシングイベントとその疾患への影響を研究する能力を高めます.
    • この研究は,人間の健康における代替スプライシングのより深い理解に貢献しています.