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Updated: Feb 14, 2026

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NEDD4-1を通じて,小分子分解剤XMU-MP-9を用いた腫瘍性K-RAS変異体をターゲットにしています

Taoling Zeng1, Tingting Jiang1, Baoding Zhang1

  • 1State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China.

Acta pharmaceutica Sinica. B
|February 13, 2026
PubMed
まとめ

新しい化合物であるXMU-MP-9は,ユビキチネーションを高めることで,がんを誘発するK-RAS変異体を標的とし,退化させます. このアプローチは,K-RAS変異がんの腫瘍細胞の増殖と発達を効果的に抑制します.

キーワード:
抗がん薬は,抗がん薬として用いられる.双機能化合物である.劣化 劣化 劣化K-RASは,K-RASという名前で,K-RASは,K-RASという名前で,NEDD4-14-1 について発がん性突然変異体による発がん性突然変異体小分子分解剤を分解する.ユビキチネーションとは

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