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Updated: Feb 14, 2026

Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts
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Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts

Published on: April 29, 2014

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LAG-3に関連したCD8+ T細胞機能不全が,子宮頸がん腫瘍の微小環境にある

Guang Zhang1,2, Lei Wang1,2, Jianhuan Chen1,2

  • 1Department of Gynecology, The First Afffliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.

Frontiers in immunology
|February 13, 2026
PubMed
まとめ

T細胞の免疫グロブリンとムチンドメイン含有-3 (LAG-3) は,子宮頸がんにおいて高度に発現し,進行段階と差異化不良と相関しています. LAG-3はCD8+T細胞の抗腫瘍機能を抑制し,がんの進行を促進する.

キーワード:
CD8+ T CD8+ Tは,CD8+ Tと一致している.免疫チェックポイントLAG-3 (地域活動グループ3)子宮頸がんは子宮頸がんである.腫瘍マイクロ環境 (TME) とは

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The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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During replication, the complementary strands in double-stranded DNA are synthesized at different rates. Replication first begins on the leading strand. Replication starts later, occurs more slowly, and proceeds discontinuously on the lagging strand.
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Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
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Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
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