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Updated: Feb 14, 2026

Flow Cytometric Analysis of Mitochondrial Reactive Oxygen Species in Murine Hematopoietic Stem and Progenitor Cells and MLL-AF9 Driven Leukemia
09:44

Flow Cytometric Analysis of Mitochondrial Reactive Oxygen Species in Murine Hematopoietic Stem and Progenitor Cells and MLL-AF9 Driven Leukemia

Published on: September 5, 2019

7.9K

MLL-r白血病の治療のためのDOT1L標的型タンパク質分解剤の開発

Songhua Quan1,2, Kenji Unno1,2, Dikshat G Gupta1,2

  • 1Department of Urology, Northwestern University Feinberg School of Medicine; Chicago, Illinois 60611, United States.

Journal of medicinal chemistry
|February 13, 2026
PubMed
まとめ

新しいタンパク質分解を標的とするキメラ (PROTACs) は,MLLによって再編成された白血病の重要な要因であるDOT1Lを効果的に退化させる. このタンパク質分解アプローチは,耐性白血病の治療に有望であることが示されています.

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