マルチターゲットのメカニズムによる抗アポプトティックおよび抗増殖剤としてのディクロロフタルアンヒドリド派生剤:生物学的評価と分子ドッキング研究

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Updated: Feb 14, 2026

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Hatem A Abuelizz1, Maha M Soltan2, Mohamed Marzouk3

  • 1Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

Journal of biochemical and molecular toxicology
|February 13, 2026
PubMed
まとめ

4,5-dichlorophthalic anhydridesから派生した新しい抗増殖剤は,乳がんに対する約束を示しています. 化合物7と9はアポトーシスとカスパース活性化を誘導し,チューブリン不安定化の可能性がありました.

キーワード:
4,5-ジクロロフタルアンヒドリド4,5-ジクロロフタルアンヒドリドVEGFR‐2は,VEGFR‐2に適合している.アポプトシス (apoptosis) とは人間のチューブリン (Human Tubulin) とはイン・シルココ・シルココ

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