関連する実験動画

Updated: Feb 14, 2026

Detection of Small GTPase Prenylation and GTP Binding Using Membrane Fractionation and GTPase-linked Immunosorbent Assay
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GTPに結合したRan GTPアゼにおけるコンフォメーションスイッチIの誘導開封

Janka Czigleczki1, Balint Dudas2, Erika Balog1

  • 1Department of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary.

Protein science : a publication of the Protein Society
|February 13, 2026
PubMed
まとめ

Ran GTPaseは,活性状態と非活性状態を切り替えることで細胞輸送を調節する. この研究は,重要な相互作用を妨害することで,活発なRanGTPを不活性状態に追い込む新しいメカニズムを明らかにし,治療の洞察を提供している.

キーワード:
ラン・ラン・ラン・ランコンフォーマーションスイッチ分子ダイナミクス 分子ダイナミクス小さなGTP酵素である.I スイッチ I スイッチ I スイッチ

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