前立腺生検前直腸スランプにおけるフルオロキノロン抵抗性の危険因子
Conor B Driscoll1, Mitchell M Huang1, Nicole Handa1
1Northwestern University, Feinberg School of Medicine, Department of Urology, Chicago, IL 60611, USA.
Urology practice
|February 13, 2026
まとめ
前立腺針生検 (PNB) を受けている患者におけるフルオロキノロン耐性 (FQR) は安定しているが,前立腺針生検の暴露や特定の人口統計などの要因に関連している. これらの患者レベルでのFQRリスクを特定することで,生検前のカウンセリングを改善し,尿路症候群のリスクを軽減することができます.
科学分野:
- 泌尿器科 泌尿器科とは
- 感染症 感染症は感染症です.
- 公衆衛生は公衆衛生である.
背景:
- 前立腺がんの診断には,しばしば前立腺針生検 (PNB) が含まれる.
- フルオロキノノロン (FQs) を含む抗生物質による生検前予防は,PNB後の泌尿症を予防することを目的としています.
- フルオロキノロン耐性 (FQR) の増加は,リスク評価の更新を必要とします.
研究 の 目的:
- 多病院システム内でPNBを受けた患者のFQRの傾向を評価する.
- FQRに関連する患者レベルの危険因子を特定するために.
主な方法:
- 2013年から2024年にかけて,PNB前直腸スワンブを施した10,372人の患者を対象に,遡及的なコホート研究を行った.
- 収集されたデータには,人口統計,併発症,および以前のFQ被曝が含まれています.
- 多変量回帰分析を使用して,FQRの危険因子を特定しました.
主要な成果:
- 全体的なFQR率は18.8%で,E. coliが最も一般的な耐性細菌でした.
- FQR率は,研究期間 (2013年-2024年) を通して安定していました.
- FQRの患者レベルの危険因子には,前回のFQ被曝,年長,未保険者,ヒスパニック系,非白人人種,および胞炎の歴が含まれています.
結論:
- 前回のFQ暴露,年齢,保険状態,民族性,人種,およびディヴェルティキュリチス病歴を含む,FQRの新規の患者レベルのリスク要因が特定されました.
- 現在のアメリカ泌尿器官学会 (AUA) のガイドラインは,FQRに関する包括的なPNB前カウンセリングのための精細化が必要になる可能性があります.
- PNB前にFQRリスクを管理するための臨床ガイドラインを更新するために,さらなる研究が必要です.
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