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Updated: Feb 14, 2026
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頭蓋骨底内視手術を受ける高齢者の嗅覚の脆弱性:嗅覚帯の上昇からの洞察
J Kim1,2, C-S Rhee2,3, I K Choi3
1Obstructive Upper Airway Research (OUaR) Laboratory, Department of Pharmacology, Seoul National University College of Medicine, Seoul, South Korea.
Rhinology
|February 13, 2026
まとめ
高齢患者 (≥50歳) は,内視内鼻アプローチ (EEA) の後,より悪い匂いの結果を経験します. 年齢は嗅覚細胞に影響しますが,S100の発現率が高くなり,手術後の嗅覚を改善する可能性があります.
科学分野:
- 耳鼻喉科 (Otorhinolaryngology) は,耳鼻喉科 (Otorhinolaryngology) を専門とする医療機関である.
- 神経科学は神経科学である.
- 老化に関する研究
背景:
- 術後の嗅覚機能不全は,内視内皮アプローチ (EEA) の既知の合併症です.
- EEAの後の嗅覚結果に対する患者の年齢の特定の影響は不明である.
- この研究では,EEA後の嗅覚回復の要因としての年齢を調査し,嗅覚粘膜の組織学的分析を含む.
研究 の 目的:
- 患者さんの年齢が,内視内鼻腔アプローチ (EEA) の後の嗅覚結果に影響を与えるかどうかを判断する.
- 嗅覚粘膜組織学における年齢に関連した変化を調べる.
- 組織学的発見を術後の嗅覚機能と相関させる.
主な方法:
- 嗅覚帯の上昇を伴うセルラー/パラセルラー腫瘍のEEAを受ける患者の遡及的レビュー.
- 嗅覚機能は,手術前および手術後6ヶ月間,クロスカルチャー・オール・アイデティフィケーション・テスト (CCSIT) と韓国嗅覚アンケート (OQ) を使用して評価されました.
- 横の基礎細胞 (HBCs),嗅覚感覚神経細胞 (OSNs),および嗅覚嗅覚細胞 (OECs) の嗅覚粘膜の免疫ヒストキミカル分析.
主要な成果:
- 43人の患者 (平均年齢53.7歳) を分析し,手術後のCCSITとOQスコアの低下を示した.
- 50歳以上の患者は嗅覚機能が著しく低下した (CCSITとOQが低下した).
- 年齢の増加は,OSN数,HBC数,および嗅覚粘膜におけるS100発現強度の低下と相関する. S100表現は嗅覚の結果と正に相関する.
結論:
- 年齢 ≥50歳は,嗅覚帯の上昇とともに,EEA後の嗅覚機能のより大きな低下と関連しています.
- 高齢化は,重要な嗅覚細胞 (OSNs,HBCs) のレベルが低下することと関連しています.
- 嗅覚粘膜におけるS100発現の上昇は,手術後の嗅覚の改善を予測する.
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