関連する実験動画

Updated: Feb 15, 2026

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
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Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

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Munc13-1はDAGとCa2+のカップルで,ダイナミックな膀プライミング,シナプス短期的な可塑性,およびテタニック後の増強にシグナルを送信します

Mrinalini Ranjan1,2, Kun-Han Lin3, Brian D Mueller4

  • 1Department of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.

Science advances
|February 13, 2026
PubMed
まとめ

ダイアシルグリセロール (DAG) とカルシウムシグナルによるMunc13-1タンパク質の調節がシナプス強度に影響します. Munc13-1へのDAG結合が低下すると,最初の放出が強化されるが,持続的な神経伝達とテタニック後の増強を弱める.

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