コルディセピンは,カタツムリ媒介のMMP2発現を抑制することによって,ヒトのエクストラヴィヨス・トロフォブラストの侵入を抑制します

Manman Guo1, Siwei Luo1, Beibei Bi1

  • 1Center for Reproductive Medicine, Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Tissue & cell
|February 13, 2026
PubMed
まとめ

コルディセピン (COR) は,アデノシン受容体とAKTシグナル伝達によって媒介される,マトリックス金属プロテイン酶2 (MMP2) 発現をダウンレギュレーションすることによって,ヒトエクストラビヨストロフォブラスト (EVT) 細胞の侵入を抑制する. これは,CORの妊娠保健サプリメントとしての可能性を示唆しています.

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