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下肢の強度の非対称性と,多発性硬化症患者の機能的変化との関連
Callie Evanchick1, Nicholas Lopez1, Elizabeth S Gromisch2
1Mercy University, 555 Broadway, Dobbs Ferry, NY, USA.
Multiple sclerosis and related disorders
|February 13, 2026
まとめ
下肢の強度の非対称性,特に膝の屈折と足首のドルシフレクションは,MS (PwMS) の患者の機能状態に大きな影響を与えます. 特定の非対称性カットオフ,特に膝の屈折は,PwMSの機能的低下を予測します.
科学分野:
- 神経学 神経学とは
- リハビリテーション・サイエンス・サイエンス
- バイオメディカルエンジニアリング
背景:
- 下肢 (LL) の非対称性は,MS (PwMS) の患者に疲労,不安定,転倒の恐れと関連しています.
- PwMSにおける機能的状態の変化に対するLL強度アシンメトリーの特定の寄与に関する研究は限られている.
研究 の 目的:
- PwMSにおける様々な機能的ステータスグループにおけるLL強度の非対称性の違いを調査する.
- PwMSにおける機能的状態の変化を示す特定の非対称性スコアを特定する.
主な方法:
- 横断的な研究では,MSウォーキングスケール (MSWS-12) を使用して機能グループに分類された183件のPwMSのデータを分析した.
- ピーク・アイソメトリック・トルクとヒップ・アブドクション/エクステンション/フレクション,膝のエクステンション/フレクション,足首のプランタルフレクション/ドルシフレクションの非対称性を測定した.
- 統計的分析には,機能グループ間の差異を調査し,非対称性のための最適なカットオフスコアを特定するために,受信機の動作特性 (ROC) の分析を行うことが含まれていました.
主要な成果:
- 膝の屈折 (KF),足首の背の屈折 (ADF),膝の伸縮 (KE) の非対称性における重要な差異が機能グループ間で観察されました.
- KF非対称性 (カットオフ≥19.74%) とADF非対称性 (カットオフ≥14.29%) は,臨床的に重要な感受性と特異性を示した.
- KF非対称性は,PwMSにおける機能的状態の有意な予測因子として浮上した (aOR: 264.75).
結論:
- PwMSにおける機能レベル間の有意な差異を示したのはKE,KF,ADFの非対称性だけでした.
- ミニマルと重度の機能群を区別する非対称性の値は,従来の10%の基準を超えました.
- KF非対称性は,機能的な変化の重要な予測因子であり,PwMSの管理におけるその重要性を強調しています.
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