腸内微生物群と認知機能の低下との関連:文献の体系的なレビュー
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Sofia Libriani1, Gabriella Facchinetti2, Flavio Marti3
1Department of Urology, Santa Rosa Hospital, Viterbo, Italy.
Nutrition research (New York, N.Y.)
|February 13, 2026
まとめ
腸内微生物群の調節は,認知症のリスクのある高齢者の認知機能の改善に有望であることが示されています. 腸内微生物群を標的とした早期の介入は,脳の健康をサポートし,認知機能低下と闘う可能性があります.
科学分野:
- 神経科学は神経科学である.
- 微生物学 微生物学とは
- ゲロントロジーはゲロントロジーの学科です.
背景:
- 腸-脳軸は,神経変性疾患において極めて重要です.
- 年齢に関連した腸内微生物群の変化は,認知機能低下や認知症を引き起こす可能性があります.
- 認知健康のために微生物群を標的とした介入が検討されている.
研究 の 目的:
- 微生物群の介入が認知成果に与える影響を体系的に検討する.
- 認知障害または認知症のリスクのある45歳以上の成人の効果を評価するために.
主な方法:
- 2025年6月までのRCTおよび準実験研究の体系的レビュー.
- 主要なデータベース (PubMed,EMBASEなど) を検索しました. ) を実施する.
- ジョアンナ・ブリッグス・インスティテュート (Joanna Briggs Institute) の基準を用いた15の研究 (4,275人の参加者) を評価した.
主要な成果:
- 微生物群の調節 (プロバイオティクス,FMT,ダイエット) は,記憶,実行機能,およびグローバルな認知を改善しました.
- 利益は,プロドロマまたは軽度の認知障害において最も顕著でした.
- 微生物の多様性,SCFAの産生,炎症の減少に関連した改善.
結論:
- 腸内微生物群の調節は,認知健康のための有望な非薬理学的戦略です.
- 早期の介入は,認知機能低下における最適な効果の鍵です.
- 効果とメカニズムを確認するために,さらなる大規模なRCTが必要である.
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