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Updated: Feb 15, 2026

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OTUD4は,ヒッポ/YAP軸経由で臓がんの進行を調節する

Shuaike Qu1, Zhihao Liu1, Beibei Wang2

  • 1Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, 110000, Liaoning Province, PR China.

Neoplasia (New York, N.Y.)
|February 13, 2026
PubMed
まとめ

OTUドメインを含むタンパク質4 (OTUD4) は,Yes-Associated Protein (YAP) を安定させることで,臓腺がん (PAAD) の進行を促進します. OTUD4を枯渇させると,Hippo/YAPの活性が低下し,PAADの成長が妨げられ,治療対象としてOTUD4が示唆される.

キーワード:
ヒッポ/YAP軸についてOTUD4は,オットゥード4である.臓アデノカルシノーマ 臓アデノカルシノーマ 臓アデノカルシノーマウビキチンは,ウビキチンの

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