関連する実験動画

Updated: Feb 15, 2026

Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta using the ex vivo Human Placental Perfusion Model
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Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta using the ex vivo Human Placental Perfusion Model

Published on: June 18, 2013

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人間の実験モデルにおけるSGLT2阻害剤の胎盤移植特性と機能的影響

Sabrina Kuoni1, Alexandra Dolder2, Roger Lehmann3

  • 1Department of Obstetrics, University Hospital Zurich, Zurich CH-8091, Switzerland; University of Zurich, Zurich CH-8091, Switzerland.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
|February 13, 2026
PubMed
まとめ

ナトリウム・グルコース共輸送体2阻害体 (SGLT2i) は,流出輸送体とタンパク質結合によって影響を受け,受動的拡散を経由して胎盤を通過します. これらの抗糖尿病薬は胎盤の糖分分解を変化させながらも胎盤機能を害することはありませんが,妊娠中の使用は禁忌です.

キーワード:
ベウォー細胞はベウォー細胞です.糖尿病 糖尿病 糖尿病プラセンタ・ペルフュージョンをex vivoで実施する.妊娠 妊娠 妊娠SGLT2 阻害剤を投与するトランスウェル (Transwell) とは

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Characteristics and Functions of Blood

Blood is specialized connective tissue comprising about 8% of the body mass. It has a thick, liquid extracellular matrix that contains cells, dissolved proteins, and electrolytes, making it five times more viscous than water. Blood is warm, around 38°C, and has an alkaline pH ranging from 7.35 to 7.45.
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Transfer Function to State Space

State-space representation is a powerful tool for simulating physical systems on digital computers, necessitating the conversion of the transfer function into state-space form. Consider an nth-order linear differential equation with constant coefficients, like those encountered in an RLC circuit. The state variables are selected as the output and its n−1 derivatives. Differentiating these variables and substituting them back into the original equation produces the state equations.
In an RLC...
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State Space to Transfer Function01:21

State Space to Transfer Function

The conversion of state-space representation to a transfer function is a fundamental process in system analysis. It provides a method for transitioning from a time-domain description to a frequency-domain representation, which is crucial for simplifying the analysis and design of control systems.
The transformation process begins with the state-space representation, characterized by the state equation and the output equation. These equations are typically represented as:
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Modeling of Diode Forward Characteristics

Understanding the behavior of diodes when forward-biased is a fundamental aspect of electronic circuit design and analysis. This analysis primarily utilizes two models: the exponential diode model and the constant-voltage-drop model. The exponential model comes into play when the source voltage exceeds 0.5 volts, pushing the diode current to rise exponentially above the saturation current. This relationship is graphically depicted in the current-voltage (I-V) curve, illustrating the diode's...
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In the standard form, the transfer function is shown in constant gain, poles/zeros at origin, simple poles/zeros, and quadratic poles/zeros; each contributing uniquely to the system's overall response. The term represents the magnitude of the simple zero:
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Transfer function and Bode Plots-I01:19

Transfer function and Bode Plots-I

A transfer function presented in its standard form integrates elements' constant gain, the zeros, and poles at the origin, simple zeros and poles, and quadratic poles and zeros. The transfer function can be written as H(ω):
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