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Updated: Feb 15, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
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Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

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1,10-フェナントロリン基リガンドを含むPt(II) とPd(II) 複合体:DNAと抗がん活動との異なる結合方式

Misaki Nakai1, Yusuke Tsutsumi1, Togo Imai1

  • 1Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, Kansai University, 3-3-35, Yamatecho, Suita-shi, Osaka 564-8680, Japan.

Journal of inorganic biochemistry
|February 13, 2026
PubMed
まとめ

プラチナとパラジウム複合体とフェナントロリンリガンドは,異なるDNA相互作用と抗がん活動を示しています. パラジウム複合体は強い細胞毒性を発揮し,特定のプラチナ複合体はシスプラチン耐性肺がんに対する有望な効果を示しています.

キーワード:
抗がん剤は,抗がん剤として用いられる.牛の血清アルブミンについてDNAの相互作用 DNAの相互作用インターカレーター (Intercalator) とはパラジウム (Palladium) とはプラチナ・プラチナ・プラチナ

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