双極性障害における脳年齢:モデル選択と臨床的要因の影響

Natasha Topolski¹, Ercole J Barsotti², Andrea Boscutti³

¹Translational Psychiatry Program, Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, (UTHealth), 77054, Houston, TX, USA; Center of Excellence in Mood Disorders, Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, 1941 East Rd, 77054, Houston, TX, USA; Neuroscience Graduate Program, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, 77054, Houston, TX, USA.

Biological psychiatry. Cognitive neuroscience and neuroimaging

|February 13, 2026

まとめ

双極性障害 (BD) は,加速された脳老化に関連しており,脳年齢はモデル全体で年代的年齢よりも高い. リチウム治療は神経保護を提供し,この脳年齢のギャップを減らすことができます.

科学分野:

神経科学は神経科学である.
精神科医は精神病を患っている.
放射線学放射線学

背景:

双極性障害 (BD) は,加速された老化に関連しています.
前回のBDにおけるBrain Ageの研究では,方法論的差異による可能性のある矛盾した結果が示されています.

研究の目的:

BDタイプI患者の3つの脳年齢モデルと対照群を比較する.
BDにおける脳年齢に対する薬物,特にリチウムの影響を調査する.

主な方法:

352人のBDタイプI患者と327人の対照群のT1加重型MRIスキャンを分析した.
3つのモデル (ENIGMA,PyBrainAge,Pyment) が予測年齢差 (PAD) を計算した.
年齢,性別,スキャナー,薬物使用状況によって制御された線形混合効果モデル.

主要な成果:

すべてのモデルでコントロールと比較してBDにおけるPADの上昇 (3.03-1.43年より高い).
タラミックと心室の体積は,BDにおけるPADの上昇に重要な貢献者でした.
リチウムで治療を受けたBD患者はPAD上昇を示さなかったが,リチウムを使用しなかった患者はPADが著しく高かった.

結論:

発見はBDにおける脳年齢の上昇を支持し,リチウムの神経保護効果を示唆しています.
脳年齢の予測は,使用されたモデル,MRIスキャナー,および薬剤の状態の影響を受けます.

キーワード:

老化のバイオマーカー双極性障害とは,双極性障害である.脳の年齢脳の年齢リチウムリチウムリチウムリチウムリチウムリチウムリチウムリチウムリチウムリチウムリチウム神経画像は,神経イメージングによるものです.構造MRIによる構造MRI

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