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ポロキサマーとポリエチレン酸化物を共同プリントされたキャリアポリマーとして使用した半固体挤出 (SSE) 3Dプリントされた薬物製剤の製剤と評価
Kristiine Roostar1, Oleh Koshovyi1, Ivo Laidmäe1
1Institute of Pharmacy, Faculty of Medicine, University of Tartu, 1 Nooruse St, Tartu 50411, Estonia.
まとめ
ポリエチレン酸化物 (PEO) と組み合わせたPoloxamer F108は,アセチルサリチル酸 (ASA) の用量フォームの半固体挤出 (SSE) 3Dプリントに最適であり,パーソナライズされた医療のための優れたプリント可能性と制御された薬物放出を提供します.
科学分野:
- 医薬品技術 医薬品技術について
- 3Dプリントのアプリケーション
- 材料科学 材料科学とは
背景:
- 半固体挤出 (SSE) 3Dプリントは,パーソナライズされた製薬用用薬剤フォームを可能にします.
- ポロキサマーとポリエチレン酸化物 (PEO) は,医薬品の配合における重要な補助物質です.
研究 の 目的:
- 医薬品用SSE3DプリントにPEOと組み合わせた異なるポロキサマーグレード (F68,F87,F108) の適性を調査する.
- ポロキサマーグレードが,アセチルサリチル酸 (ASA) 装填用薬剤の物理化学的特性,印刷可能性,およびインビトロ薬剤の放出に及ぼす影響を評価する.
主な方法:
- ポロキサマーとPEO (55:45 w/w) の二元混合物を水性ゲルに調製した.
- アセチルサリシル酸 (ASA) は,5%,7%および9% (w/w) の濃度で組み込まれました.
- SSE 3Dプリントは4x4グリッドと軸に穴をあけたタブレットを作成するために使用され,その後,特性の特徴化とインビトロ薬剤の放出が行われました.
主要な成果:
- ポロキサマーF108は,SSE 3Dプリントに適した高粘度ゲルを形成し,F68とF87はプリントフィデリティが低下した.
- FTIRスペクトロスコーピーは,ASA,PEO,およびすべてのポロキサマーグレードの互換性を確認しました.
- SSE 3Dプリントグリッドは,F87 > F68 > F108.8の順番で薬物放出率で即時放出行動を示した.
結論:
- ポーロキサマーF108は,PEOと組み合わせた場合,ASAでロードされた用量フォームのSSE 3Dプリントのための最も実現可能なキャリアポリマーです.
- 開発されたポロキサマー-PEO製剤は,即時放出口服薬剤の水性SSE3Dプリントのための実行可能なプラットフォームを提供します.
- このアプローチは,高度な3Dプリント技術を通じて,パーソナライズされた医療と複合治療の設定をサポートしています.
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