関連する実験動画

Updated: Feb 15, 2026

Generation of Defined Genomic Modifications Using CRISPR-CAS9 in Human Pluripotent Stem Cells
09:04

Generation of Defined Genomic Modifications Using CRISPR-CAS9 in Human Pluripotent Stem Cells

Published on: September 25, 2019

8.8K

大規模なCRISPR-Cas9スクリーンは,免疫チェックポイントのレギュレータを定義します

Michael Mu1, Johannes C Melms1, Patricia Ho1

  • 1Columbia University Vagelos College of Physicians and Surgeons, New York, NY, United States; Department of Medicine, Division of Hematology and Oncology, Columbia University Irving Medical Center, New York, NY, United States; Columbia Center for Translational Immunology, New York, NY, United States; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, United States.

Methods in cell biology
|February 13, 2026
PubMed
まとめ

研究者はCRISPR-Cas9スクリーニングとFACSを使用して,がんにおける免疫チェックポイントを研究しました. この方法は,遺伝子の変化が免疫チェックポイントの調節にどのように影響するかを特定し,がん治療の開発を支援するのに役立ちます.

キーワード:
CRISPR-Cas9は,CRISPR-Cas9と一致している.FACS (ファックス) とは免疫不全症候群 免疫不全症候群 免疫不全症候群とはスクリーニング スクリーニング

さらに関連する動画

Cell Surface Receptor Identification Using Genome-Scale CRISPR/Cas9 Genetic Screens08:49

Cell Surface Receptor Identification Using Genome-Scale CRISPR/Cas9 Genetic Screens

Published on: June 6, 2020

15.4K
Gene Knock-in by CRISPR/Cas9 and Cell Sorting in Macrophage and T Cell Lines11:32

Gene Knock-in by CRISPR/Cas9 and Cell Sorting in Macrophage and T Cell Lines

Published on: November 13, 2021

11.6K

関連する概念動画

CRISPR01:59

CRISPR

Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
58.0K
CRISPR and crRNAs02:53

CRISPR and crRNAs

Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...
19.2K
CRISPR/Cas9 Genome Editing01:28

CRISPR/Cas9 Genome Editing

The CRISPR-Cas system serves as a bacterial defense mechanism against invading genetic elements such as viruses and plasmids, forming the foundation for its adaptation as a powerful genome-editing tool. Originally discovered in prokaryotes, this system has been repurposed to revolutionize genetic engineering across a wide range of organisms, including plants, animals, and humans. The core component, Cas9, is an endonuclease derived from Streptococcus pyogenes, capable of introducing...
2.0K
The Spindle Assembly Checkpoint02:19

The Spindle Assembly Checkpoint

The spindle assembly checkpoint is a molecular surveillance mechanism ensuring the fidelity of chromosome segregation during anaphase. The checkpoint monitors the completion of all the prerequisite steps before chromosome segregation to determine whether the segregation process should proceed or be delayed.
Many proteins function together to control the spindle assembly checkpoint. Mutations affecting these proteins may allow cells to proceed into anaphase prematurely, resulting in the...
3.9K
pH Scale02:41

pH Scale

Hydronium and hydroxide ions are present both in pure water and in all aqueous solutions, and their concentrations are inversely proportional as determined by the ion product of water (Kw). The concentrations of these ions in a solution are often critical determinants of the solution’s properties and the chemical behaviors of its other solutes. Two different solutions can differ in their hydronium or hydroxide ion concentrations by a million, billion, or even trillion times. A common means of...
80.5K
What is the Immune System?01:38

What is the Immune System?

Overview
133.1K