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Updated: Feb 15, 2026

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
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Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

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キテニン-CCL20軸は,膠芽細胞腫における免疫抑制性腫瘍微環境を調節するための潜在的な治療標的である

Eun-Jung Ahn1, Sung Sun Kim2, Sm Abdus Salam1

  • 1Department of Neurosurgery, Chonnam National University Hwasun Hospital and Medical School, Hwasun, South Korea; Department of Pathology, Chonnam National University Hwasun Hospital and Medical School, Hwasun, South Korea.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
|February 13, 2026
PubMed
まとめ

KAI1 COOH-ターミナル相互作用テトラスパニン (KITENIN) は,CCキモカインリガンド20 (CCL20) を増加させることで,膠芽細胞腫の免疫抑制を促進します. このKITENIN-CCL20経路をターゲットにすることで,免疫抑制細胞を減少させ,抗腫瘍免疫力を高めることで,グリオブラストームの免疫療法を改善することができます.

キーワード:
CCL20 CCL20 CCL20 CCL20 CCL20 CCL20 CCL20グリオブラストーマ (glioblastoma) とは免疫抑制は免疫を抑制する.キテニニンはキテニンです.ミエロイド系由来の抑制細胞である.腫瘍のマイクロ環境

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