タウは,Pseudomonas aeruginosaによって引き起こされる血脳障壁機能不全に必要である

Samantha D Chaney^1,2, Allison J Bauman², Evan-Angelo R Butlig¹

¹Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.

Communications biology

|February 13, 2026

まとめ

肺感染症は,認知症に関連した脳の変化を引き起こします. この研究は,タウタンパク質が肺炎による血脳障壁損傷と脳炎症に不可欠であることを示し,認知機能低下との新たな関連を示唆しています.

科学分野:

神経科学は神経科学である.
免疫学免疫学とは
感染症感染症とは

背景:

肺感染症,特に細菌性肺炎は,認知症のリスクの増加と関連しています.
肺炎中に肺から放出される細胞毒性タウタンパク質は,認知機能の欠陥と脳内のタウの種を発生させる可能性があります.
肺感染症と神経炎症や認知症を結びつける正確なメカニズムは,まだ完全に理解されていません.

研究の目的:

肺炎が血脳障壁 (BBB) の浸透性,膠質活性化,および脳内のタウリン酸化に及ぼす影響を調査する.
肺炎に起因する脳病理を媒介するタウタンパク質の役割を決定する.

主な方法:

C57BL/6Jとタウ・ノックアウト (KO) のマウスを含むマウスモデルが使用されました.
肺感染症は,Pseudomonas aeruginosa (P. aeruginosa) を使用して誘発されました.
BBBの透過性,膠質活性化 (アストロサイト活性化),およびリン酸化タウ (ptau) レベルは,感染後24時間評価されました.

主要な成果:

肺炎は,C57BL/6Jマウスの脳におけるBBBの透過性,アストロサイトの活性化,およびptauのレベルを著しく増加させた.
タウ・ノックアウトマウスは,肺炎の後に重要なBBB損傷や膠質活性化を示さなかった.
感染したC57BL/6Jとtau KOのマウスは,特定のキナーゼと炎症誘発性サイトカインのレベルが上昇した.

結論:

タウタンパク質は,肺炎に起因する血脳障壁機能障害と天体細胞の反応性の重要な媒介です.
タウは,肺感染症と認知症の発症を結びつける先天的な免疫応答の構成要素として機能する可能性があります.
ターゲティングタウは,呼吸器感染症後の認知機能低下を防ぐための治療戦略を提供することができる.

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