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Updated: Feb 15, 2026

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腸内細菌によるO-脱メチル化は,経口エトポシドに対する全身的曝露を調節する

Ashutosh Tripathi1, Toe Ein Kyawt2, Jongoh Shin3

  • 1Department of Pharmaceutical Sciences and Center for Biomolecular Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA.

Gut microbes
|February 13, 2026
PubMed
まとめ

腸内微生物は,薬剤をO-デメチル化し,薬剤の効果を変えることができる. この研究では,エトポシドを含む64の薬物のうち35の薬物のO-脱メチル化活性が,その有効性と毒性に影響することを発見しました.

キーワード:
腸内微生物群 (gut microbiota) は,腸内微生物群 (gut microbiota) と呼ばれている.O-脱メチル化によるO脱メチル化エトポシド エトポシドファルマコキネティクス 薬理学エクセノビオティック代謝

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