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Updated: Feb 15, 2026

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats
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Published on: December 2, 2016

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uPAR欠乏がTGFβ1媒介の線維性改造を誘発し,心周血管状の微環境を形成する

Yulia Goltseva1, Zoya Tsokolaeva2,3, Irina Beloglazova2

  • 1National Medical Research Centre of Cardiology named after academician E.I. Chazov, Moscow, 121552, Russian Federation. YDgoltseva@cardio.ru.

Stem cell research & therapy
|February 14, 2026
PubMed
まとめ

ウロキナーゼプラズミノゲンアクティベーター受容体 (uPAR) の喪失は,周周微環境を混乱させ,TGFβ1信号伝達を増幅することによって,心筋線維症を悪化させます. これは,PARを線維性心疾患の潜在的な治療標的として強調しています.

キーワード:
3D細胞培養で細胞培養する.心臓圏 (cardiosphere) とは,心臓圏 (cardiosphere) と呼ばれるものです.繊維芽細胞 (Fibroblasts) は,繊維芽細胞 (Fibroblasts) と呼ばれている.線維症 (Fibrosis) とはハート ハート ハート ハート ハート周周血管のマイクロ環境です.スフィロイドは,球形状のものです.TGFβ1は,TGFβ1と関係している.ウパール UPARウロキナーゼ受容体とは

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