関連する実験動画

Updated: Feb 15, 2026

An Improved Protocol to Purify and Directly Mono-Biotinylate Recombinant BDNF in a Tube for Cellular Trafficking Studies in Neurons
13:46

An Improved Protocol to Purify and Directly Mono-Biotinylate Recombinant BDNF in a Tube for Cellular Trafficking Studies in Neurons

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マイクログリアルBDNF/TrkBシグナル伝達媒介によるKCC2機能障害 早期脳卒中後の発作感受性を悪化させる

Jing Zhou1,2, Benjamin H Wang1, Jiangning Yu1

  • 1Department of Neurosurgery and Neurology, Institutes of Brain Science, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institute of Biological Science, Zhongshan Hospital, Fudan University, Shanghai, China.

CNS neuroscience & therapeutics
|February 14, 2026
PubMed
まとめ

マイクログリア由来BDNF/TrkBシグナリングはKCC2機能を損なっており,脳卒中後の発作リスクを高めます. この経路を阻害したり,KCC2を強化したりすることで,脳卒中後のに対する新しい治療戦略が提供されます.

キーワード:
BDNF,BDNF,BDNFをはじめとするTrkBB トークBB でした.クロリドホメオスタシス発血性脳卒中 発血性脳卒中とはマイクログリアのミクログリアカリウム塩化物共輸送体 2 2発作,発作が発作する.

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Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins09:07

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