特質神経症とノセボ効果:副作用期待の仲介的な役割

Anton Fischer¹, Li-Ching Chuang¹, Nick Augustat¹

¹Philipps-Universität Marburg, Department of Psychology, Section Personality and Diagnostics, Marburg, Germany.

Journal of personality

|February 14, 2026

まとめ

高度な神経症は,否定的な副作用の期待を高めることで,個人におけるノセボ反応を高めます. これらの期待は,神経症症と,医療処置中により身体的症状を経験するとの関連を部分的に媒介する.

科学分野:

心理学心理学とは
精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは
医学社会学医学社会学

背景:

神経症は,否定的な期待や身体的苦情と関連しています.
過剰な否定的な期待は,医療治療に対するノセボ反応の重要な要因である.

研究の目的:

副作用の期待が神経症とノセボ反応の関係を媒介するかどうかを調査する.
健康な個人を対象とした薬理学的研究で,この関係を検証する.

主な方法:

275人の参加者は,プラセボまたはスルピリドを受け取る前に神経症と期待を報告しました.
2x2の因数式設計には,物質対プラセボと期待の操作が含まれていました.
ソマティック症状は,基線および介入中に評価されました.

主要な成果:

ニューロティシズムは,ベースラインの体症状と,介入前の期待値と相関していた.
神経症と期待の両方が,ノセボ反応を予測した.
予防介入の期待は,神経症症とノセボ反応の関連を部分的に媒介した.

結論:

神経症に関連した否定的な期待は,ノセボ反応に寄与する.
これはフィードバックループを作り,副作用を悪化させ,ネガティブな期待を強める可能性があります.

キーワード:

神経症候群ニューロティシズム神経症候群ノセボ効果 (Nocebo Effect) とは,ノセボ効果 (Nocebo Effect) とは,ノセボ効果 (Nocebo Effect) とは,ノセボ効果 (Nocebo Effect) とは,ノセボ効果 (Nocebo Effect) とは,ノセボ効果 (Nocebo Effect) とは,ノセボ効果 (Nocebo Effect) とは,副作用の期待についてソマティック症状は,体内症状である.治療への期待治療への期待

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