エンドミックエリアからの病院内移転後にカンジダ・オーリスのコロニー化を検出するための検査,前向きな観察研究
Laura Mezzogori1,2, Martina Bavastro1,2, Laura Magnasco2
1Department of Health Sciences, University of Genoa, Genoa, Italy.
Mycoses
|February 14, 2026
まとめ
移送前にCandida aurisのスクリーニングスランプが1回だけ陰性であるだけでは,コロニー化を排除するには不十分です. 移植後2週間以内に繰り返しスクリーニングを行うことは,コロニー化を検出し,感染を防ぐために非常に重要です.
科学分野:
- 感染症 感染症は感染症です.
- クリニカル・マイクロバイオロジー
- 病院疫学 病院疫学について
背景:
- 国際的なガイドラインには,Candida aurisの風土病棟から非風土病棟に移転した患者の管理に関する明確な勧告がない.
- コロニゼーションを排除するための最適なタイミングとスクリーニングスワンプの数は不明のままです.
研究 の 目的:
- 移植後のスクリーニングプロトコルの有効性を評価し,未入植の患者におけるCandida aurisのコロニー化を検出する.
- Candida auris.の水平伝播を防ぐために最適なスクリーニング戦略を決定する.
主な方法:
- Candida aurisに感染しているICUから非流行病病棟に移転した成人の患者に関する見通し観察研究.
- 移植後の0~1日,2~3日,その後毎週実施される部/部スワンプのリアルタイムPCRスクリーニング.
- 移植後の4週間以内に≥2個のスランプが陰性であった場合,十分にスクリーニングされたと考えられた患者.
主要な成果:
- 440人の非入植患者のうち,208人が十分なスクリーニングを受け,移植後のCandida auris検査で16.3%が陽性でした.
- 移植前スワンプが陰性だった患者の7.1%が後に陽性になった.
- Candida auris candidemiaは,新たに検出された移植後のコロニゼーションを有する患者の11.8%で発生しました.
結論:
- 移植前スクリーニングの1つのネガティブなスワンプは,Candida aurisのコロニー化を排除するのに不十分です.
- 移植後の最初の2週間以内に繰り返しスクリーニングを行うことは,正確な検出のために不可欠です.
- 効果的なスクリーニングプロトコルは,医療施設でのCandida aurisのさらなる感染を防ぐために不可欠です.
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