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Updated: Feb 15, 2026

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
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メチル β-C ((sp3) -H経由でスピロカルボサイクルの合成 サイクルアリファ酸の機能化

Tao Sheng1, Zhihan Zhao1, Yilin Lu1

  • 1Department of Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, United States.

Journal of the American Chemical Society
|February 14, 2026
PubMed
まとめ

研究者らは,循環カルボキシル酸のメチルC-H結合を選択的に活性化するために新しいリガンド (MPAAとMPAThio) を開発した. これにより,さまざまなスパイロサイクルの化合物の新合成が可能になり,薬用アプリケーションのためのカーボサイクルの化学を拡張します.

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