関連する実験動画

Updated: Feb 16, 2026

Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance
09:48

Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance

Published on: February 17, 2023

3.5K

インスリン抵抗性: 展開されたタンパク質応答,糖尿病,癌の間の収束の中心的なノード

K M Abdullah1, Gunjan Sharma1, Baby Anjum2

  • 1Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS, 39216, USA; Cancer Center and Research Institute, University of Mississippi Medical Center, Jackson, MS, 39216, USA.

Molecular aspects of medicine
|February 14, 2026
PubMed
まとめ

肥満はインスリン抵抗性 (IR) と2型糖尿病 (T2D) を誘発し,がんのリスクを増大させます. 展開タンパク質応答 (UPR) とミトコンドリア関連膜 (MAM) の失調は,これらの状態を結びつけ,治療標的を提供する.

キーワード:
がん がん がん がん がん糖尿病 糖尿病 糖尿病エンドプラズマ網膜のストレスストレスインスリン抵抗性 インスリン抵抗性とはミトコンドリア関連膜解き放たれたタンパク質応答.

さらに関連する動画

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

6.2K
Immunohistochemical Analysis in the Rat Central Nervous System and Peripheral Lymph Node Tissue Sections09:11

Immunohistochemical Analysis in the Rat Central Nervous System and Peripheral Lymph Node Tissue Sections

Published on: November 14, 2016

17.9K

関連する概念動画

The Unfolded Protein Response01:37

The Unfolded Protein Response

The ER is the hub of protein synthesis in a cell. It has robust systems to quality control protein folding and also for degradation of terminally misfolded proteins. Under normal conditions, a small proportion of misfolded proteins that cannot be salvaged need to be transported to the cytoplasm by the ER-associated degradation or ERAD pathways. However, if the ERAD cannot handle the misfolded proteins, the cell activates the unfolded protein response or UPR to adjust the protein folding...
6.5K
Regulation of the Unfolded Protein Response01:31

Regulation of the Unfolded Protein Response

Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
3.1K
Convergent Evolution01:54

Convergent Evolution

Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.
33.1K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
511
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.8K
The Central Dogma01:25

The Central Dogma

Overview
140.1K